Methanesulfonyl chloride → HCID 20199143, compound

HRID 652106Notes

Reaction equation

HRID 652106 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:21]=[CH:22][CH:23]=1)[O:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:17]([CH3:18])[N:16]=[C:15]([CH2:19][NH2:20])[N:14]=1)[CH3:3].[CH3:24][S:25](Cl)(=[O:27])=[O:26]>N1C=CC=CC=1>[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:21]=[CH:22][CH:23]=1)[O:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:17]([CH3:18])[N:16]=[C:15]([CH2:19][NH:20][S:25]([CH3:24])(=[O:27])=[O:26])[N:14]=1)[CH3:3]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 20199123HCID 20199123, compound

Product 1

HCID 20199143HCID 20199143, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 5-[[3-[3-[(Dimethylamino)methyl]phenoxy]propyl]amino]-1-methyl-1H-1,2,4-triazole-3-methanamine (0.75 g) and methane sulphonyl chloride (0.18 ml) in dry pyridine (15 ml) was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was dissolved in aqueous sodium carbonate and extracted with ethyl acetate. The organic solution was evaporated leaving the title compound (0.5 g). T.l.c. System B, Rf 0.6.

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in aqueous sodium carbonate
  3. extractionextracted with ethyl acetate
  4. customThe organic solution was evaporated

Sources & evidence

ORD record
ord-b75f4591db7843e8be0130f5f533dc0c
Source dataset
uspto-grants-1987_06
Patent number
US04670448

Reaction notes

Loading…