4-Chlorobenzoyl chloride → HCID 14032625, compound

HRID 652154Notes

Reaction equation

HRID 652154 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([F:18])=[CH:15][CH:16]=3)[NH:11][N:10]=2)[CH2:5][CH2:4]1)[CH3:2].[Cl:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>CCOCC>[ClH:19].[Cl:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([N:11]2[C:12]3[C:17](=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=3)[C:9]([CH:6]3[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]3)=[N:10]2)=[O:25])=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 178462536HCID 178462536, compound

Product 1

HCID 14032625HCID 14032625, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3.0 g of 3-(1-ethyl-4-piperidinyl)-6-fluoro-1H-indazole and 8 ml of 4-chlorobenzoyl chloride was heated at 100° C. in a steam bath for 4 hrs. Ether was added and the solid was collected. The solid was recrystallized twice from ethanol-ether to yield 2.9 g (57%) of product, mp 240°-242° C.

Workup

  1. customthe solid was collected
  2. customThe solid was recrystallized twice from ethanol-ether

Sources & evidence

ORD record
ord-dad9db0a839a46f096d73aa0a944d703
Source dataset
uspto-grants-1987_06
Patent number
US04670447

Reaction notes

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