HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → Quinacainol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 1-[2-(1,1-Dimethyl-ethyl)-4-quinolyl]-3-(4-piperidyl)-1-propanone | HCID 15581672 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Quinacainol | HCID 55464 | — |
| Product | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
Reaction Steps
The operation was as in Example 5, starting from 14 g of the dihydrochloride of 1-[2-(1,1-dimethyl-ethyl)-4-quinolyl]-3-(4-piperidyl)-1-propanone, 4.15 g of sodium methylate and 1.8 g of sodium borohydride in 150 ml of methanol. 4.1 g were finally obtained of 1-[2-(1,1-dimethyl-ethyl)-4-quinolyl]-3-(4-piperidyl)-1-propanol (racemic), in the form of the dihydrochloride melting at 219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04613607 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-d293db95ad074643b3f0c80070633f3e |
| Source note | uspto-grants-1986_09 |