Isopropylamine → HCID 20199603, compound

HRID 652220Notes

Reaction equation

HRID 652220 reaction equation
C(N)(C)C.C1OC1C.[CH:9]([N:12]([CH2:17][CH:18]([OH:20])[CH3:19])[CH2:13][CH:14]([OH:16])[CH3:15])([CH3:11])[CH3:10]>>[CH:9]([N:12]1[CH2:17][CH:18]([CH3:19])[O:20][C:14]([CH3:15])([OH:16])[CH2:13]1)([CH3:11])[CH3:10]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 6378Propylene OxideHCID 13644129HCID 13644129, compound

Product 1

HCID 20199603HCID 20199603, compoundYield 32%

Procedure

Isopropylamine (11.8 g, 0.2 mol) and propylene oxide (34.8 g, 0.6 mol) were subjected to a reaction as described in Example 1 above, except that the reaction temperature was 165° C. A 32% yield of 4-isopropyl-2,6-dimethyl-2-hydroxymorpholine was obtained along with 50% of N-isopropyl-bis-(2-hydroxypropyl)amine.

Workup

  1. customwas 165° C

Sources & evidence

ORD record
ord-f0fbec34f1254cff815a8426159e5097
Source dataset
uspto-grants-1987_06
Patent number
US04670557

Reaction notes

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