Ammonia → 4-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine
Reaction equation
[NH3:1].[CH:2]1([C:5]2[N:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7](OC)[N:6]=2)[CH2:4][CH2:3]1>CO>[NH2:1][C:7]1[N:6]=[C:5]([CH:2]2[CH2:3][CH2:4]2)[N:10]=[C:9]([O:11][CH3:12])[N:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 140 °C
Procedure
Gaseous ammonia is blown through a solution of 5 g of 2-cyclopropyl-4,6-dimethoxy-1,3,5-triazine in 30 ml of methanol at room temperature until saturation is reached. The solution is then stirred in a bomb tube (autoclave) at 140° C. for 1 hour; it is subsequently cooled, and the reaction mixture is filtered to thus obtain 0.5 g of the title product as light-brown crystals, m.p. 156°-157° C.
Workup
- temperatureit is subsequently cooled
- filtrationthe reaction mixture is filtered to thus obtain 0.5 g of the title product as light-brown crystals, m.p. 156°-157° C.
Sources & evidence
- ORD record
- ord-cef6cf5ff10e432f93bd639d88985412
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04670559
Reaction notes
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