Sodium Hydroxide → HCID 4379030, compound

HRID 652234Notes

Reaction equation

HRID 652234 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH2:10][N:11]2[CH:15]([C:16]([O:18]C)=[O:17])[CH2:14][CH2:13][C:12]2=[O:20])[CH:7]=[CH:8][CH:9]=1>O>[Cl:3][C:4]1[CH:5]=[C:6]([CH2:10][N:11]2[C:12](=[O:20])[CH2:13][CH2:14][CH:15]2[C:16]([OH:18])=[O:17])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13662512HCID 13662512, compound

Product 1

HCID 4379030HCID 4379030, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 16.00 g of sodium hydroxide pellets in 165 ml of water was treated with 99.01 g of (±)-1-[(3-chlorophenyl)methyl]-5-methoxycarbonyl-2-pyrrolidinone and was heated for two hours with a steam bath. The solution was cooled to room temperature and extracted with diethyl ether (2×300 ml). The aqueous phase was acidified with 45 ml of concentrated hydrochloric acid and extracted with dichloromethane (3×200 ml). Crystals precipitated out of the dichloromethane. The crystals (80.21 g, damp with solvent) were dried overnight at 65° C. under vacuum.

Workup

  1. temperaturewas heated for two hours with a steam bath
  2. extractionextracted with diethyl ether (2×300 ml)
  3. extractionextracted with dichloromethane (3×200 ml)
  4. customCrystals precipitated out of the dichloromethane
  5. customThe crystals (80.21 g, damp with solvent) were dried overnight at 65° C. under vacuum

Sources & evidence

ORD record
ord-554f692499004110aa3a90661c329913
Source dataset
uspto-grants-1987_06
Patent number
US04670562

Reaction notes

Loading…