HCID 54243088, compound → HCID 13519092, compound

Participants

Reaction Steps

A solution of 7.5 g of 17α-acetoxy-1-chloromethyl-6-methylene-4-pregnene-3,20-dione in 66 ml of γ-collidine is stirred for one hour at a bath temperature of 180° C. and then poured on an ice water-sodium chloride solution. The mixture is filtered off and the residue worked up as usual. The crude product is purified on 700 g of silica gel with a hexane-ethyl acetate gradient. Yield: 4.3 g of 17α-acetoxy-1α,2α-methylene-6-methylene-4 pregnene-3,20-dione, mp 205°-206° C.

Provenance & Evidence