HCID 13519092, compound → HCID 56637783, compound

Participants

Reaction Steps

Under argon, 500 mg of 17α-acetoxy 1α,2α-methylene-6-methylene-4-pregnene-3,20-dione is agitated for 16 hours in 30 ml of methanol and 16 ml of 5% sodium hydroxide solution. The mixture is poured on an ice water-sodium chloride solution and worked up as usual. The crude product is purified on 50 g of silica gel with a hexane-acetone gradient, thus isolating 380 mg of 17α-hydroxy-1α,2α-methylene-6-methylene-4-pregnene-3,20-dione.

Provenance & Evidence