HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[4-(3-ethoxy-2-hydroxypropoxy)phenyl]-3-(methylsulfonyl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(4-Aminophenoxy)-3-ethoxypropan-2-ol | HCID 10774857 | — |
| Reactant | 3-(Methylsulfonyl)propionyl chloride | HCID 20199855 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(3-ethoxy-2-hydroxypropoxy)phenyl]-3-(methylsulfonyl)propionamide | HCID 13657123 | 94.2% |
Reaction Steps
A 2.11 g quantity of 4-(3-ethoxy-2-hydroxypropoxy)aniline and 1.53 g of triethylamine were dissolved in 50 ml of dichloromethane. To the solution was added 1.71 g of 3-(methylsulfonyl)propionyl chloride with ice cooling. The same subsequent procedure as in Example 2 was repeated and recrystallization from benzene was performed, giving 3.25 g of N-[4-(3-ethoxy-2-hydroxypropoxy)phenyl]-3-(methylsulfonyl)propionamide in a yield of 94.2 %. M.p. 111° to 112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04670583 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-6892363b853443e7aa0580139f31fe9f |
| Source note | uspto-grants-1987_06 |