1-Hexanamine, hydrochloride → HCID 178444829, compound

HRID 652291Notes

Reaction equation

HRID 652291 reaction equation
Cl.[CH2:2]([NH2:8])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[N-:9]([C:12]#[N:13])[C:10]#[N:11].[Na+]>C(O)CCC>[C:10]([NH:9][C:12](=[NH:13])[NH:8][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])#[N:11]

Participants

4

Reactant 2

HCID 673421-Hexanamine, hydrochlorideHCID 4350929Sodium dicyanamide

Product 1

HCID 178444829HCID 178444829, compoundYield 51.5%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of hexylamine hydrochloride (63.5 g.), sodium dicyanamide (44.5 g.) and butanol (200 ml.) was heated at reflux for 18 hours and then cooled. The mixture was filtered and the filtrate was evaporated to dryness. The residue was stirred with water and the insoluble solid was collected and crystallised from aqueous ethanol to give 3-cyano-1-hexylguanidine (40 g.) m.p. 103°-105°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 18 hours
  3. temperaturecooled
  4. filtrationThe mixture was filtered
  5. customthe filtrate was evaporated to dryness
  6. customthe insoluble solid was collected
  7. customcrystallised from aqueous ethanol

Sources & evidence

ORD record
ord-8bedaf1270064866bb04778bbd37bb49
Source dataset
uspto-grants-1987_06
Patent number
US04670592

Reaction notes

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