Isopropylamine → HCID 3550524, compound

Temperature

0 °C

Dichloroacetyl chloride, 442.5 grams (3.0 mole), was dissolved in a flask containing 900 milliliters of methylene chloride and the solution cooled to 0° C. in an ice/acetone bath. 354 grams (5.98 mole) of isopropyl amine was added dropwise with vigorous stirring and the addition rate was adjusted to maintain the reaction temperature below 5° C. When the addition was complete, the mixture was allowed to stir at ambient temperature for one hour then washed with 2×500 milliliters water, the organic phase separated, dried over magnesium sulfate and stripped of solvent at reduced pressure giving 499 grams (98% yield) of the desired product, a white solid, m.p. 45°-48° C.

1. temperatureto maintain the reaction temperature below 5° C
2. additionWhen the addition
3. stirringto stir at ambient temperature for one hour
4. washthen washed with 2×500 milliliters water
5. customthe organic phase separated
6. dry with materialdried over magnesium sulfate

ORD record

ord-3891246f27e4482a92d8af954f01cd03

Source dataset

uspto-grants-1987_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04670593