Isopropylamine → HCID 13885084, compound

HRID 652297Notes

Reaction equation

HRID 652297 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[F:5][CH:6]([Cl:12])[C:7](OCC)=[O:8]>C(O)C.C(O)CO>[CH:1]([NH:4][C:7](=[O:8])[CH:6]([Cl:12])[F:5])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 6363IsopropylamineHCID 101668Acetic acid, 2-chloro-2-fluoro-, ethyl ester

Product 1

HCID 13885084HCID 13885084, compound

Reagents, catalysts & solvents 2

HCID 174Ethylene GlycolCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 11.8 grams (0.2 mole) isopropyl amine in 20 milliliters ethyl alcohol were added dropwise at 10°-15° C. with stirring to a solution of ethyl fluorochloroacetate and 5 drops of ethylene glycol in 80 milliliters ethyl alcohol. The solution was stirred at 10°-20° C. for 2 hours and was then stored at -15° C. for 3 days. At this time, the solution was evaporated to leave a liquid, 25.2 grams, nD30 1.4395, identified as the title compound by infrared and nuclear magnetic resonance spectroscopy.

Workup

  1. waitwas then stored at -15° C. for 3 days
  2. customAt this time, the solution was evaporated
  3. customto leave a liquid, 25.2 grams

Sources & evidence

ORD record
ord-52dc0d6660124f188cdacf971dec5896
Source dataset
uspto-grants-1987_06
Patent number
US04670593

Reaction notes

Loading…