Isopropylamine → HCID 13885086, compound

HRID 652298Notes

Reaction equation

HRID 652298 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[Br:5][CH:6]([F:12])[C:7](OCC)=[O:8]>C(O)C.C(O)CO>[CH:1]([NH:4][C:7](=[O:8])[CH:6]([Br:5])[F:12])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 6363IsopropylamineHCID 2733407Acetic acid, 2-bromo-2-fluoro-, ethyl ester

Product 1

HCID 13885086HCID 13885086, compound

Reagents, catalysts & solvents 2

HCID 174Ethylene GlycolCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 14.8 grams (0.25 mole) isopropyl amine in 25 milliliters ethanol was added dropwise to a solution of ethyl bromofluoroacetate, 40 grams (0.22 mole), and 5 drops ethylene glycol in 100 milliliters ethyl alcohol at 10°-15° C. The solution was stirred at 10°-20° C. for 2 hours and was then stored at -15° C. for 3 days. At this time, the solution was evaporated to leave a liquid, 41.8 grams, nD30 1,4629, identified by infrared spectroscopy as the title compound.

Workup

  1. waitwas then stored at -15° C. for 3 days
  2. customAt this time, the solution was evaporated
  3. customto leave a liquid, 41.8 grams

Sources & evidence

ORD record
ord-95834474fe5a420e91489adcba7b3b0e
Source dataset
uspto-grants-1987_06
Patent number
US04670593

Reaction notes

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