反应详情

A solution of 20 grams (0.16 mole) of ethyl difluoroacetate in 20 milliliters ethyl alcohol was added slowly in a solution of 9.5 grams (0.16 mole) isopropylamine amine and 5 drops of ethylene glycol in 30 milliliters ethyl alcohol. The temperature rose slowly to 27° C. The mixture was then refluxed for 3 days. After this reflux period, the solution was evaporated at 100 millimeters and the residue was distilled at atmospheric pressure to yield 18.0 grams, b.p. 86°-88°, identified by infrared spectroscopy as the title compound.

1. customrose slowly to 27° C
2. temperatureThe mixture was then refluxed for 3 days
3. waitAfter this reflux period
4. customthe solution was evaporated at 100 millimeters
5. distillationthe residue was distilled at atmospheric pressure
6. customto yield 18.0 grams, b.p. 86°-88°