Isopropylamine → HCID 13885088, compound

HRID 652299Notes

Reaction equation

HRID 652299 reaction equation
[F:1][CH:2]([F:8])[C:3]([O:5]CC)=O.[CH:9]([NH2:12])([CH3:11])[CH3:10]>C(O)C.C(O)CO>[CH:9]([NH:12][C:3](=[O:5])[CH:2]([F:1])[F:8])([CH3:11])[CH3:10]

Participants

5

Reactant 2

HCID 6363IsopropylamineHCID 9961Ethyl difluoroacetate

Product 1

HCID 13885088HCID 13885088, compound

Reagents, catalysts & solvents 2

HCID 174Ethylene GlycolCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 20 grams (0.16 mole) of ethyl difluoroacetate in 20 milliliters ethyl alcohol was added slowly in a solution of 9.5 grams (0.16 mole) isopropylamine amine and 5 drops of ethylene glycol in 30 milliliters ethyl alcohol. The temperature rose slowly to 27° C. The mixture was then refluxed for 3 days. After this reflux period, the solution was evaporated at 100 millimeters and the residue was distilled at atmospheric pressure to yield 18.0 grams, b.p. 86°-88°, identified by infrared spectroscopy as the title compound.

Workup

  1. customrose slowly to 27° C
  2. temperatureThe mixture was then refluxed for 3 days
  3. waitAfter this reflux period
  4. customthe solution was evaporated at 100 millimeters
  5. distillationthe residue was distilled at atmospheric pressure
  6. customto yield 18.0 grams, b.p. 86°-88°

Sources & evidence

ORD record
ord-fddf133ee643458aa7f84b78309ea1d6
Source dataset
uspto-grants-1987_06
Patent number
US04670593

Reaction notes

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