化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → (E)-1-(4-Chloro-1-butenyl)-4-fluorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | alpha-Cyclopropyl-4-fluorobenzenemethanol | HCID 102498 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | (E)-1-(4-Chloro-1-butenyl)-4-fluorobenzene | HCID 20188301 | — |
反応手順
Dissolve 12.8 g (0.077 mole) of α-cyclopropyl-4-fluorobenzenemethanol in 60 ml of CHCl3, add 20 ml of concentrated HCl and reflux overnight. Separate the two layers, and extract the aqueous layer with methylene chloride. Combine the methylene chloride extracts with the chloroform layer and wash with saturated aqueous sodium bicarbonate, and dry over magnesium sulfate. Evaporate the organic solvents to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04613609 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-2e3a2ad4ee894bbea0d45c4ba970aa58 |
| 出典メモ | uspto-grants-1986_09 |