HCID 13727808, compound → HCID 13727773, compound

Participants

Reaction Steps

To a solution of 9.1 g (24.9 mmol) of [(phenylmethoxy)carbonyl]-L-leucine, 2-(trimethylsilyl)ethyl ester in 200 ml of ethyl acetate cooled in an ice bath under nitrogen was added 1 g of 10% palladium on charcoal. The reaction mixture was subjected to a steady stream of hydrogen for 21/2 hours at room temperature, then filtered and concentrated in vacuo to remove volatiles. The liquid product obtained was homogeneous by TLC. The yield was 5.8 g and the free amino-ester was used directly without further characterization.

Provenance & Evidence