Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
BOC-D-alanine → Boc-(D)Ala-Gly-OBzl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | BOC-D-alanine | HCID 637606 | — |
| 반응물 | O-benzylglycine toluene-p-sulphonate | HCID 6451311 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Boc-(D)Ala-Gly-OBzl | HCID 15567200 | 90.8% |
반응 단계
Boc-D-Ala-OH (5.68 g, 30 mmole) and H-Gly-OBzl.TosOH (10.6 g, 1.05 eq) were suspended in CH2Cl2. WSCI (6 ml, 1.1 eq) was added dropwise while cooling, and the solution was stirred overnight. The CH2Cl2 was distilled off. The residue was dissolved in AcOEt (500 ml); washed with 1N HCl, water, 5% NaHCO3, and water in order; and dried over Na2SO4. AcOEt was distilled off, and the residue was recrystalized twice with AcOEt/n-hexane to give the desired product (9.16 g, 90.7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04670540 |
| 출처 데이터셋 | uspto-grants-1987_06 |
| ORD ID | ord-704b84efe0ee494a8263c3f78ceb2203 |
| 출처 메모 | uspto-grants-1987_06 |