Glycine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-D-alanyl]-, phenylmethyl ester → HCID 71355766, compound

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Reaction Steps

Boc-Phe-D-Ala-Gly-OBzl (2.4 g, 4.96 mmole) was dissolved in MeOH (50 ml), and H2 gas was passed through the solution in the presence of Pd-C for 4 hours. Pd-C was removed by filtration, and MeOH was distilled off. To the thus-obtained residue MeOH/Et2O and N-hexane were added. The thus-precipiated powder was separated by filtration and reprecipitated with AcOEt/n-hexane to obtain the desired product (1.95 g, 100%). (4) Synthesis of Z-Cys(4-CH3Bzl)-Phe-D-Ala-Gly-OH

Provenance & Evidence