HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-hydroxy-7-nitro-2H-1,4-benzoxazin-3-(4H)-one → 7-Amino-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-hydroxy-7-nitro-2H-1,4-benzoxazin-3-(4H)-one | HCID 21298685 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Amino-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one | HCID 21298683 | — |
Reaction Steps
The 6-hydroxy-7-nitro-2H-1,4-benzoxazin-3-(4H)-one (17.5 g) in DMF (300 ml) was reduced under 60 Atm. hydrogen at 60° C. in the presence of Ni Raney catalyst in an autoclave. The resulting amine was not isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04672013 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-fdf33b79928641419186850626ffffa2 |
| Source note | uspto-grants-1987_06 |