Propane sultone → HCID 88491333, compound

Participants

Reaction Steps

In a round bottom flask fitted with a stirrer and reflux condenser were placed 50.0 g of tetrahydroquinoline, 48.8 g of 1,3-propanesultone and 500 ml of reagent grade acetonitrile solvent. The mixture was heated at reflux under a nitrogen blanket overnight. The reaction mixture was cooled to ice-bath temperature and the resulting white solid precipitate filtered and washed with cold acetonitrile. A yield of 58 g (60%) of crude product was obtained with a melting point over 200° . Nuclear magnetic resonance (NMR) and mass spectrometry analyses showed the product to be consistent with the assigned structure.

Provenance & Evidence