Methyl formate → HCID 12803101, compound

HRID 652441Notes

Reaction equation

HRID 652441 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][C:12]#[N:13].[CH:14](OC)=[O:15]>>[C:12]([CH2:11][C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([NH:1][CH:14]=[O:15])[CH:3]=2)[NH:7][CH:6]=1)#[N:13]

Participants

3

Reactant 2

HCID 7865Methyl formateHCID 12803100HCID 12803100, compound

Product 1

HCID 12803101HCID 12803101, compound

Procedure

A solution of 5-amino-1H-indole-3-acetonitrile (0.5 g) in methyl formate (20 ml) was stirred at room temperature for 24 h. The resulting solid precipitate was filtered off, washed with ether (2×20 ml) and dried in vacuo to give the title compound (0.41 g) as a white microcrystalline solid m.p. 196°-200° (softens 194°).

Workup

  1. filtrationThe resulting solid precipitate was filtered off
  2. washwashed with ether (2×20 ml)
  3. customdried in vacuo

Sources & evidence

ORD record
ord-4e48d28e419c4c9eab82b1182a63a68e
Source dataset
uspto-grants-1987_06
Patent number
US04672067

Reaction notes

Loading…