Sodium Cyanate → HCID 12803121, compound

HRID 652447Notes

Reaction equation

HRID 652447 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][N:14]1[C:22](=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]1=[O:24].[O-:25][C:26]#[N:27].[Na+]>O>[O:23]=[C:22]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15](=[O:24])[N:14]1[CH2:13][CH2:12][C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[C:3]([CH2:2][NH:1][C:26]([NH2:27])=[O:25])[CH:4]=2)[NH:8][CH:7]=1

Participants

4

Reactant 2

HCID 517096Sodium CyanateHCID 12803116HCID 12803116, compound

Product 1

HCID 12803121HCID 12803121, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of 2-[2-[5-(aminomethyl)-1H-indol-3-yl]ethyl]-1H-isoindole-1,3-(2H)-dione, hemisulphate, hydrate (1.01 g) in hot water (27 ml) was treated with a solution of sodium cyanate (0.25 g) in water (9 ml) and heated on a steam bath for 1.5 h. The reaction mixture was cooled and filtered, affording the title urea as a white crystalline solid (0.82 g) m.p. 230°-2°.

Workup

  1. temperatureheated on a steam bath for 1.5 h
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-c7c3e3201f0b48efa7d0fee0f0f10633
Source dataset
uspto-grants-1987_06
Patent number
US04672067

Reaction notes

Loading…