HCID 20197294, compound → HCID 20197297, compound

Participants

Reaction Steps

A solution of 3-[2-[methyl(phenylmethyl)amino]ethyl]-1H-indole-5-carbonitrile (1.3 g) in dry tetrahydrofuran (100 ml) under nitrogen was treated with lithium aluminium hydride (1.0 g) and heated at reflux for 3 h. Excess lithium aluminium hydride was destroyed with wet tetrahydrofuran, the reaction mixture diluted with ethyl acetate (200 ml), filtered and the filtrate evaporated to dryness to give a pale yellow oil which slowly crystallised to give the title compound as a cream solid (1.2 g) m.p. 84°-5°.

Provenance & Evidence