Ammonium Chloride → HCID 178439700, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-3-(2-chloro-4-cyanophenoxy)propane (776 mg), ammonium chloride (700 mg), sodium azide (700 mg) and dimethylformamide (2 ml) was heated at 120° C. for 1 hour. After the inorganic salt was filtered off, the filtrate was concentrated under reduced pressure. The residue was acidified with 1N-HCl and the resultant precipitate was recovered by filtration. Recrystallized from methanol gave 659 mg of 1-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-3-[2-chloro-4-(tetrazol-5-yl)phenoxy]propane as white microcrystals. m.p. 214°-216° C.

Provenance & Evidence