HCID 13686730, compound → HCID 13686732, compound

Participants

Reaction Steps

In 40 ml of acetic acid was dissolved 4.00 g of Nα -(t-butyloxycarbonyl-alanyl-D-isoglutaminyl)-Nε -benzyloxycarbonyl-lysine benzyl ester, and the solution was hydrogenolyzed in the presence of palladium-on-carbon in a hydrogen stream at room temperature. The catalyst was removed by filtration, and the filtrate was concentrated. To the residue was added diethyl ether, and the precipitated powder was recrystallized from methanoldiethyl ether to obtain 2.37 g of Nα -(t-butyloxycarbonylalanyl-D-isoglutaminyl)-lysine.

Provenance & Evidence