Butyric Acid → HCID 13686761, compound

HRID 652471Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@H:9]([C:11]([NH:13][C@@H:14]([C:29](=[O:31])[NH2:30])[CH2:15][CH2:16][C:17]([NH:19][C@H:20]([C:26]([OH:28])=[O:27])[CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])=[O:18])=[O:12])[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:32](O)(=[O:36])[CH2:33][CH2:34][CH3:35]>>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:11]([NH:13][C@@H:14]([C:29](=[O:31])[NH2:30])[CH2:15][CH2:16][C:17]([NH:19][C@H:20]([C:26]([OH:28])=[O:27])[CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:32](=[O:36])[CH2:33][CH2:34][CH3:35])=[O:18])=[O:12])[CH3:10])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 264Butyric Acid

HCID 13686732HCID 13686732, compound

Product 1

HCID 13686761HCID 13686761, compound

Procedure

In the same manner as described in Example 1-(2), 1.50 g of Nα -(t-butyloxycarbonyl-alanyl-D-isoglutaminyl)-lysine and 1.01 g of an N-hydroxy-5-norbornene-2,3-dicarboxyimide active ester of butyric acid were reacted to obtain 1.57 g of Nα -(t-butyloxycarbonyl-alanyl-D-isoglutaminyl)-Nε -butyryl-lysine; melting point: 84°-87° C. (decomp.); [α]D25 -12.2° (c 0.9, methanol).

Sources & evidence

ORD record: ord-8ad271c7d1f2451c9f8c6218c3f06258
Source dataset: uspto-grants-1987_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04672106

Reaction notes

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