4-(Pyridin-2-yl)butan-1-amine → 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(2-pyridinyl)butyl]hexanamide

HRID 652483Notes

Reaction equation

HRID 652483 reaction equation
[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2].[N:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29][CH2:30][CH2:31][CH2:32][NH2:33]>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH:33][CH2:32][CH2:31][CH2:30][CH2:29][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][N:23]=2)=[O:16])=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 135110834-(Pyridin-2-yl)butan-1-amineHCID 137538736-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid

Product 1

HCID 139127756-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(2-pyridinyl)butyl]hexanamide

Procedure

6-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid was allowed to react with 2-pyridine butanamine according to procedure A and the product was purified by crystallization from ether-hexane to give 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(2-pyridinyl)butyl]hexanamide, the title compound, mp 63°-66° in 76% yield,

Workup

  1. customthe product was purified by crystallization from ether-hexane

Sources & evidence

ORD record
ord-b067bebf9dd64bb096a5d362a478340a
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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