Pyridine, 3-(4-aminobutyl)- → HCID 13912787, compound

HRID 652488Notes

Reaction equation

HRID 652488 reaction equation
[C:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]#[C:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=O)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2].[N:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][CH2:31][CH2:32][CH2:33][NH2:34])[CH:25]=1>>[C:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]#[C:11][CH2:12][CH2:13][CH2:14][C:15]([NH:34][CH2:33][CH2:32][CH2:31][CH2:30][C:26]2[CH:25]=[N:24][CH:29]=[CH:28][CH:27]=2)=[O:17])=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 13753880HCID 13753880, compound

Product 1

HCID 13912787HCID 13912787, compound

Procedure

7-(4-Acetyl-3-hydroxy-2-propylphenoxy)-5-heptynoic acid was allowed to react with 3-pyridine butanamine according to procedure A and the product was purified by HPLC to give 7-(4-acetyl-3-hydroxy-2-propylphenoxy)-N-[4-(3-pyridinyl)butyl]-5-heptynamide, the title compound, mp 77°-80° (from ethyl acetate-hexane) in 53% yield.

Workup

  1. customthe product was purified by HPLC

Sources & evidence

ORD record
ord-9ecad26bf5274bc6a8290b4dcc7a24d3
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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