Pyridine, 3-(4-aminobutyl)- → HCID 13912788, compound

HRID 652489Notes

Reaction equation

HRID 652489 reaction equation
[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]#[C:13][C:14]([OH:16])=O)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2].[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[CH:24]=1>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]#[C:13][C:14]([NH:33][CH2:32][CH2:31][CH2:30][CH2:29][C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)=[O:16])=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 13753879HCID 13753879, compound

Product 1

HCID 13912788HCID 13912788, compound

Procedure

6-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hexynoic acid was allowed to react with 3-pyridine butanamine according to procedure B and the product was purified by chromatography on silica gel to give 6-(4-acetyl-3-hydroxy- 2-propylphenoxy)-N-[4-(3-pyridinyl)butyl]-2-hexynamide, the title compound, mp 84°-86° (from hexane) in 42% yield.

Workup

  1. customthe product was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-c0cdb2c1ba284dd8bc3ce02d91193fc8
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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