Pyridine, 3-(4-aminobutyl)- → HCID 13912789, compound

HRID 652491Notes

Reaction equation

HRID 652491 reaction equation
[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH:10]([CH3:15])[CH2:11][C:12]([OH:14])=O)=[C:6]([CH2:18][CH2:19][CH3:20])[C:5]=1[OH:21])(=[O:3])[CH3:2].[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][CH2:29][CH2:30][CH2:31][NH2:32])[CH:23]=1>>[C:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH:10]([CH3:15])[CH2:11][C:12]([NH:32][CH2:31][CH2:30][CH2:29][CH2:28][C:24]2[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=2)=[O:14])=[C:6]([CH2:18][CH2:19][CH3:20])[C:5]=1[OH:21])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 20225908HCID 20225908, compound

Product 1

HCID 13912789HCID 13912789, compound

Procedure

4-(4-Acetyl-3-hydroxy-2-propylphenoxy)-3-methyl butanoic acid was allowed to react with 3-pyridinebutanamine according to procedure A and the product was purified by HPLC to give 4-(4-acetyl-3-hydroxy-2-propylphenoxy)-3-methyl-N-[4-(3-pyridinyl)butyl]-butanamide, the title compound, mp 58°-60° (from ethyl acetate-hexane) in 84% yield.

Workup

  1. customthe product was purified by HPLC

Sources & evidence

ORD record
ord-6aca1142d724491c9cc0cae0e30d07f2
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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