Pyridine, 3-(4-aminobutyl)- → HCID 13912790, compound

HRID 652492Notes

Reaction equation

HRID 652492 reaction equation
[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=O)=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2].[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[CH:24]=1>>[C:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][CH2:9][CH2:10][C:11]([CH3:16])([CH3:15])[C:12]([NH:33][CH2:32][CH2:31][CH2:30][CH2:29][C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)=[O:14])=[C:6]([CH2:19][CH2:20][CH3:21])[C:5]=1[OH:22])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 20225902HCID 20225902, compound

Product 1

HCID 13912790HCID 13912790, compound

Procedure

4(4-Acetyl-3-hydroxy-2-propylphenoxy)-2,2-dimethyl butanoic acid was allowed to react with 3-pyridine butanamine according to procedure A and the product was purified by HPLC to give 4-(4-acetyl-3-hydroxy-2-propylphenoxy)-2,2-dimethyl-N-[4-(3-pyridinyl)butyl]-butanamide, the title compound, mp 80°-83° (from hexane) in 83% yield.

Workup

  1. customthe product was purified by HPLC

Sources & evidence

ORD record
ord-2709aabdc8944d1d95c95547d3c39001
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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