Pyridine, 3-(4-aminobutyl)- → HCID 13912801, compound

HRID 652500Notes

Reaction equation

HRID 652500 reaction equation
[C:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=2)=[C:6]([CH2:24][CH2:25][CH3:26])[C:5]=1[OH:27])(=[O:3])[CH3:2].[N:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][CH2:35][CH2:36][CH2:37][NH2:38])[CH:29]=1>>[C:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:21]=[CH:20][C:16]([C:17]([NH:38][CH2:37][CH2:36][CH2:35][CH2:34][C:30]3[CH:29]=[N:28][CH:33]=[CH:32][CH:31]=3)=[O:18])=[CH:15][CH:14]=2)=[C:6]([CH2:24][CH2:25][CH3:26])[C:5]=1[OH:27])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 72927Pyridine, 3-(4-aminobutyl)-HCID 13019309HCID 13019309, compound

Product 1

HCID 13912801HCID 13912801, compoundYield 93%

Procedure

The reaction of 0.635 g of 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]benzoic acid with 0.28 g of 3-pyridine butanamine according to Example 40 gave 0.80 g, mp 133°-134°, (93% yield) of 4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]-N-[4-(3-pyridinyl)butyl]benzamide, the title compound.

Sources & evidence

ORD record
ord-871db36896b448dd95779e9fcf97d2a1
Source dataset
uspto-grants-1987_06
Patent number
US04672066

Reaction notes

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