反应详情

To 5.6 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid ethyl ester in 50 ml of methanol was added 50 ml of 1.0N sodium hydroxide and the solution was stirred at reflux for 2 hours. The methanol was removed in vacuo, the residue was acidified and the product was extracted with ether. The dried (over magnesium sulfate) extract was concentrated in vacuo to a solid which was recrystallized from ether-hexane to give 4.18 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid, the titled compound, mp 128°-130°, (83% yield).

1. temperatureat reflux for 2 hours
2. customThe methanol was removed in vacuo
3. extractionthe product was extracted with ether
4. dry with materialThe dried (over magnesium sulfate)
5. extractionextract
6. concentrationwas concentrated in vacuo to a solid which
7. customwas recrystallized from ether-hexane