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Potassium Carbonate → 11-(4-Acetyl-3-hydroxy-2-propylphenoxy)undecanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 11-bromoundecanoate | HCID 223913 | — |
| 反応物 | 2',4'-Dihydroxy-3'-propylacetophenone | HCID 2775198 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 11-(4-Acetyl-3-hydroxy-2-propylphenoxy)undecanoic acid methyl ester | HCID 54082735 | 76% |
反応手順
A mixture of 1.00 g of 1-(2,4-dihydroxy-3-propylphenyl) ethanone, 1.44 g of methyl 11-bromoundecanoate and 1.00 g of anhydrous potassium carbonate in 20 ml of anhydrous dimethyl formamide was stirred and heated at 75° for 2 hours. The usual workup followed by chromatography on 30 g of silica gel and elution with 10% ethyl acetate-toluene gave 1.48 g (76% yield) of 11-(4-Acetyl-3-hydroxy-2-propylphenoxy) undecanoic acid methyl ester, the titled compound, as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04672066 |
| 出典データセット | uspto-grants-1987_06 |
| ORD ID | ord-c8cab5f079b84cf28b1bcac2cfc79ff9 |
| 出典メモ | uspto-grants-1987_06 |