Sodium Hydroxide → 4[(4-Acetyl-3-hydroxy-2-propylphenoxy) methyl]-2-ethoxybenzoic acid
Reaction equation
C([O:3][C:4](=[O:29])[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[C:15]([OH:22])[C:14]=2[CH2:23][CH2:24][CH3:25])=[CH:7][C:6]=1[O:26][CH2:27][CH3:28])C.[OH-].[Na+]>>[C:19]([C:16]1[CH:17]=[CH:18][C:13]([O:12][CH2:11][C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:29])=[O:3])=[C:6]([O:26][CH2:27][CH3:28])[CH:7]=2)=[C:14]([CH2:23][CH2:24][CH3:25])[C:15]=1[OH:22])(=[O:21])[CH3:20]Participants
3
Procedure
4-[(4-Acetyl-3-hydroxy-2-propylphenoxy)methyl]-2-ethoxybenzoic acid ethyl ester was allowed to react with 1.0N sodium hydroxide according to the procedure of Example 70 and the product was purified by recrystallization from methanol to give 4[(4-acetyl-3-hydroxy-2-propylphenoxy) methyl]-2-ethoxybenzoic acid, the title compound, m.p. 145°-150° in 93% yield.
Workup
- customthe product was purified by recrystallization from methanol
Sources & evidence
- ORD record
- ord-6fa056ad9bd64c85a2b256b8f23e40f6
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04672066
Reaction notes
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