HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → 2-[4-(2-Benzyloxyethoxy)phenyl]ethylacetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | 1-(2-Hydroxyethyl)-4-(2-benzyloxyethoxy)benzene | HCID 20197537 | — |
| Product | 2-[4-(2-Benzyloxyethoxy)phenyl]ethylacetoacetate | HCID 131714715 | — |
Reaction Steps
Diketene (3-buteno-β-lactone, available, e.g., from Aldrich Chemical Co.) is then added to the hydroxyalkylbenzene derivative 4 under basic conditions, e.g., using triethylamine in dimethoxyethane (DME) to form a ω-phenylalkylacetoacetate derivative (5). For example, 1-(2-hydroxyethyl)-4-(2-benzyloxyethoxy)benzene is reacted with diketene to afford 2-[4-(2-benzyloxyethoxy)phenyl]ethylacetoacetate (5) (Step 5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04672071 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-88550f60f5f04a07943febe0240c039f |
| Source note | uspto-grants-1987_06 |