HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → p-(Benzyloxy)phenethyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | p-(Benzyloxy)phenethyl alcohol | HCID 3017260 | 80.2% |
Reaction Steps
A solution of 14.0 g of methyl 4-benzyloxyphenylacetate (7) in THF was slowly added with stirring to a solution of 2.0 g LAH in 500 mL of THF. The mixture was heated at reflux 1 h, cooled with ice, then treated sequentially with 2 mL water, 2 mL 15% NaOH, and 4 mL of water. The mixture was filtered and the filtrate evaporated to yield 10 g of crystalline 1-benzyloxy-4-(2-hydroxyethyl)benzene (8), m.p. 84°-85° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04672071 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-d3262109a67541dc99bc6ba412d024aa |
| Source note | uspto-grants-1987_06 |