HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → 2-(Benzyloxyphenyl)ethylacetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Diketene | HCID 12661 | — |
| Reactant | N-Boc-2-(4-aminophenyl)ethanol | HCID 11413715 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Product | 2-(Benzyloxyphenyl)ethylacetoacetate | HCID 131714716 | — |
Reaction Steps
A solution of 4.9 g of 1-benzyloxy-4-(2-hydroxyethyl)benzene (8) in 100 mL of dimethoxyethane (DME) and 5 drops triethylamine was heated to reflux and 1.8 mL of diketene was slowly added. The solvent was removed under reduced pressure to yield 6.4 g of 2-(benzyloxyphenyl)ethylacetoacetate (9), m.p. 54°-56° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04672071 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-fca7c66d172340d7893718d26ba6eab6 |
| Source note | uspto-grants-1987_06 |