反应详情

Heat a mixture of 5 g (0.019 mole) of N-[4-[2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 5 mL of iodomethane and 25 mL of methanol in a pressure tube at 75° C. for about 24 hours. Cool the mixture to room temperature and remove the solvents in vacuo. Slurry the residue in acetone (50 mL) and filter and wash with acetone (100 mL). Drying provides the title compound, which may be recrystallized from methanol.

1. temperatureHeat
2. customremove the solvents in vacuo
3. filtrationfilter
4. washwash with acetone (100 mL)
5. customDrying