Hydrochloric Acid → Zantac

Participants

Reaction Steps

Concentrated hydrochloric acid (1.4 ml) was added to a solution of ranitidine (6 g ) in 2-methylpropan-2-ol. The mixture was stirred at 40° to allow the product to crystallise and the resulting slurry was cooled to 20°. Further concentrated hydrochloric acid (about 0.2 ml) was added to the mixture and, after stirring for 1 h at 20° the product was filtered off, washed with 2-methylpropan-2-ol, and dried at 50° under reduced pressure to give Form 2 ranitidine hydrochloride (5.96 g) m.p. 141°-142°.

Provenance & Evidence