HCID 13765531, compound → HCID 13765532, compound

HRID 652575Notes

Reaction equation

HRID 652575 reaction equation
[CH3:1][CH:2]([CH2:16][NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:3](NC(OCC)=O)[NH:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[H][H]>C(O)C.[Pd]>[CH3:1][CH:2]([CH2:3][NH:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:16][NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

5

Reactant 2

HCID 13765531HCID 13765531, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13765532HCID 13765532, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10 g of the 2-methyl-1,1,3-tri(ethoxycarbonylamino)propane obtained in stage a) are dissolved in 90 ml of ethanol, 3 g of palladium on active carbon (10% Pd) are added, and hydrogenation is carried out in a stirred autoclave at 165° C. and 100 bar of hydrogen for 15 hours. Complete conversion gives 2-methyl-1,3-di(ethoxycarbonylamino)propane with a selectivity of 96%.

Workup

  1. customis carried out in a stirred autoclave at 165° C.

Sources & evidence

ORD record
ord-2ab0ecf2863349ec9b16a1f231fd6f65
Source dataset
uspto-grants-1987_06
Patent number
US04672137

Reaction notes

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