Sodium Iodide → HCID 178482462, compound

Participants

Reaction Steps

A solution of 8-chloro-2,5,6-trimethoxy-4-methylaminoquinazoline (1.80 g, 0.0054 moles), sodium iodide (0.989 g, 0.0066 moles) and glacial acetic acid (50 ml) was refluxed for 8 minutes. The glacial acetic acid was removed in vacuo and the residue was diluted with water (100 ml). After extracting the aqueous solution with dichloromethane (2×25 ml) the combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. Recrystallization of the residue from ethyl acetate-isopropanol afforded the product (0.530 g), mp 219°-221° C.

Provenance & Evidence