反应详情

To a solution of 480 mg of potassium hydroxide in 40 ml of ethanol were added 2.0 g of α-methanesulfonyloxymethyl-β-(p-methoxyphenyl)-γ-butyrolactone and 1.6 ml of cyclohexylmercaptan and the resulting mixture was kept at room temperature for 4 hours. After completion of the reaction, the reaction mixture was diluted with 200 ml of ethyl ether, washed with water and saturated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 600 mg (yield 22%) of the title compound.

1. customAfter completion of the reaction
2. washwashed with water and saturated saline
3. dry with materialdried over magnesium sulfate
4. distillationthe solvent was distilled off
5. customThe crude product thus obtained
6. customwas purified by a silica gel column chromatography