Ethanol → HCID 178503891, compound

Participants

Reaction Steps

A mixture of 32 g (0.2 mole) of 4-cyanophenyl isothiocyanate and 12.8 g (0.2 mole) of monosodium cyanamide in 100 cm3 of absolute ethanol is kept at the boiling point for 2 hours. After cooling, the resulting precipitate is filtered and washed with 200 cm3 of absolute ethanol. The solid is then suspended in a solution of dimethyl sulfate (25 g, that is, 0.2 mole) in 500 cm3 of ethanol; the mixture is heated for 2 hours at the boiling temperature. The final precipitate is filtered, washed with 2×100 cm3 of water and with 2×100 cm3 of ethanol, then dried in vacuo. 32.8 g (yield 70%) of a white solid with a melting point of 220°-225° C. are obtained.

Provenance & Evidence