Ethyl chloroformate → HCID 70431093, compound

Participants

Reaction Steps

To a solution of 18.9 g 3-phenyl-1H-indol-2-ethanamine in 220 ml methylene chloride are added 15.3 ml of chloroformic ethyl ester followed by 110 ml water. The mixture is stirred for 10 minutes. 6.4 g sodium hydroxide in 100 ml water are added and stirring is continued for further 20 minutes at room temperature. The organic phase is separated, washed once with 2N tartaric acid and water, dried and evaporated under reduced pressure. The oily residue of the heading compound is used without further purification.

Provenance & Evidence