HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 14210344, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 14210343 | HCID 14210343 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 14210344 | HCID 14210344 | — |
Reaction Steps
A solution of 17.5 ml chloroacetyl chloride in 100 ml chloroform is added dropwise within 15 minutes to a solution of 50.1 g N-methyl-3-phenyl-1H-indol-2-ethanamine and 30.7 ml triethylamine in 500 ml chloroform. After 30 minutes the mixture is made alkaline with aqueous ammonia. The organic phase is separated, washed with water and dried. Evaporation of the solvent gives the heading compound, m.p. 135°-138° (from methylene chloride/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04673674 |
| Source dataset | uspto-grants-1987_06 |
| ORD ID | ord-6b0dc2a0587944f18beea626d96153c0 |
| Source note | uspto-grants-1987_06 |