関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Piperidin-4-ol | HCID 79341 | — |
| 反応物 | 1-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene | HCID 13251817 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-[3-(4-Tert-butylphenyl)-2-methylpropyl]piperidin-4-ol | HCID 13607663 | 72% |
反応手順
106 g of Na2CO3 are added to a solution of 112 g of 3-(4-tert.-butylphenyl)-2-methyl-propyl chloride and 50 g of 4-hydroxypiperidine in 1 liter of dimethylformamide (DMF). The batch is heated at 150° C. for 15 hours and then concentrated, and the residue is taken up in CH2Cl2. The CH2CL2 phase is washed with water, dried over Na2SO4 and concentrated. Distillation of the crude product gives 103 g of N-[3-(4-tert.-butylphenyl)-2-methyl-propyl]-4-hydroxypiperidine [A] as a pale yellowish oil. Boiling point 175°-178° C./0.4 mbar.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04673683 |
|---|
| 出典データセット | uspto-grants-1987_06 |
|---|
| ORD ID | ord-ee422c24821142349a1f0d89ae2c6e72 |
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| 出典メモ | uspto-grants-1987_06 |
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