Ammonium Hydroxide → HCID 20196477, compound

Participants

Reaction Steps

To a stirred solution of potassium nitrate (10 g) in conc-sulfuric acid (50 ml) was added slowly a solution of 3,4-dihydro-4-methylisoquinoline (12 g) in conc-sulfuric acid (50 ml) at -20°~-10° C. over a period of an hour. The reaction mixture was allowed to stir at ambient temperature for 3 hours and heated at 60° C. for 1.5 hours. The reaction mixture was poured onto ice, and adjusted to alkaline pH with 28% ammonium hydroxide under cooling. The resulting brown solid was filtered off, washed with water, and dried in vacuo to give 3,4-dihydro-4-methyl-7-nitroisoquinoline (14.63 g).

Provenance & Evidence