Sodium Hydroxide → HCID 23674856, compound

HRID 652741Notes

Reaction equation

HRID 652741 reaction equation
[CH3:1][CH:2]([CH:27]([CH3:30])[CH2:28][CH3:29])[C:3]([NH:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([CH3:26])=[CH:11][N:12]3[C:19](=[O:20])[C:18]([C:21]([O:23]CC)=[O:22])=[CH:17][N:16]=[C:13]32)=[CH:8][CH:7]=1)=[O:4].[OH-].[Na+:32]>CO>[CH3:1][CH:2]([CH:27]([CH3:30])[CH2:28][CH3:29])[C:3]([NH:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([CH3:26])=[CH:11][N:12]3[C:19](=[O:20])[C:18]([C:21]([O-:23])=[O:22])=[CH:17][N:16]=[C:13]32)=[CH:8][CH:7]=1)=[O:4].[Na+:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13606800HCID 13606800, compound

Product 1

HCID 23674856HCID 23674856, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of ethyl 10-(2,3-dimethylpentanoylamino)-7-methyl-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (520 mg) and 1N aqueous sodium hydroxide (3.6 ml) in aqueous methanol (25 ml) was stirred at room temperature for 2 days. Methanol was added to the reaction mixture until nearly all the precipitate was dissolved. The solution was concentrated to a half volume under reduced pressure and then filtered. The filtrate was diluted with water and allowed to stand in a refrigerator. The resultant precipitate was collected, washed with water and dried to give sodium 10-(2,3-dimethylpentanoylamino)-7-methyl-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (210 mg).

Workup

  1. dissolutionwas dissolved
  2. concentrationThe solution was concentrated to a half volume under reduced pressure
  3. filtrationfiltered
  4. additionThe filtrate was diluted with water
  5. customThe resultant precipitate was collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-fed539bdaabe4e1f98012ddfe4c225c9
Source dataset
uspto-grants-1987_06
Patent number
US04673676

Reaction notes

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