反应详情

1,290 ml of 22° Be. ammonia is placed in a 3 liter flask fitted with an agitator and a thermometer. It is cooled, and 805 g of 2-methoxy-4-bromo-5-chlorosulphonyl-benzoic acid is added in stages between 0° and +10° C. The reaction medium is agitated for 1 hour at about +10° C. then the solution is filtered with charcoal. The filtrate is diluted with 300 ml of water and the acid precipitated by adding hydrochloric acid (density 1.18). The precipitate is drained, washed with water and dried in an oven at 50° C. 645 g (85%) of product is obtained, melting at 256° C.

1. custom1,290 ml of 22° Be
2. customfitted with an agitator
3. temperatureIt is cooled
4. filtrationthe solution is filtered with charcoal
5. additionThe filtrate is diluted with 300 ml of water
6. customthe acid precipitated
7. additionby adding hydrochloric acid (density 1.18)
8. washwashed with water
9. customdried in an oven at 50° C